Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.
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DOI:
10.1152/physiol.00040.2013
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发表时间:
2014-03
期刊:
Physiology (Bethesda, Md.)
影响因子:
--
通讯作者:
Zaccolo M
Zaccolo M
中科院分区:
其他
文献类型:
--
作者:
Lomas O;Zaccolo M

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Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.
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