Diabetic angiopathy and angiogenic defects.
Diabetic angiopathy and angiogenic defects.
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DOI：
10.1186/1755-1536-5-13
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发表时间：
2012-08-01
期刊：
影响因子：
--
通讯作者：
Koya D
中科院分区：
文献类型：
--
作者：
Xu L;Kanasaki K;Kitada M;Koya D
糖尿病是世界上最严重的健康问题之一。糖尿病的主要并发症是血管疾病，称为血管病，其特征在于异常的血管生成。在这篇综述中，我们重点关注糖尿病并发症中的血管生成异常，并讨论其作为糖尿病血管并发症治疗靶点的优点和缺点。此外，我们还讨论了与非典型糖尿病并发症（如癌症）中异常血管生成相关的葡萄糖代谢缺陷。
Diabetes is one of the most serious health problems in the world. A major complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this review, we focus on angiogenesis abnormalities in diabetic complications and discuss its benefits and drawbacks as a therapeutic target for diabetic vascular complications. Additionally, we discuss glucose metabolism defects that are associated with abnormal angiogenesis in atypical diabetic complications such as cancer.