Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?
Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?
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DOI：
10.1016/j.clim.2006.09.002
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发表时间：
2006-12-01
影响因子：
8.6
通讯作者：
Fraziano, Maurizio
中科院分区：
文献类型：
--
作者：
Garg, Sanjay K.;Santucci, Marilina B.;Fraziano, Maurizio
鞘氨醇1-磷酸（S1 P）最近被报道在体外和体内结核分枝杆菌感染的小鼠模型中诱导抗分枝杆菌活性。然而，其在人类肺结核过程中的作用仍然未知。这项研究表明，肺结核（TB）患者气道表面液中的S1 P水平明显低于非TB对照患者。此外，来自S1 P结核病患者的支气管肺泡灌洗细胞的体外刺激显着减少了内源性分支杆菌分离株的细胞内生长。这些结果表明，在肺结核的过程中，气道上皮细胞。液体相关S1 P可能在抑制细胞内分枝杆菌生长中起保护作用，其减少可能代表了一种新的致病机制，通过这种机制，M.结核病有利于其复制。(c)2006年爱思唯尔公司All rights reserved.
Sphingosine 1-phosphate (S1P) has recently been reported to induce antimycobacterial activity in vitro and in a mouse model of in vivo Mycobacterium tuberculosis infection. However, its rote in the course of pulmonary tuberculosis in humans is still not known. This study shows that S1P levels in airway surface fluid of tuberculosis (TB) patients are significantly less than those observed in non-TB control patients. Moreover, the in vitro stimulation of bronchoalveolar lavage cells coming from TB patients with S1P significantly reduces intracellular growth of endogenous mycobacterial isolates. These results show that, in the course of pulmonary TB, airway epithelial. fluid-associated S1P may play a protective role in the containment of intracellular mycobacterial growth and that its decrease may represent a novel pathogenic mechanism through which M. tuberculosis favors its replication. (c) 2006 Elsevier Inc. All rights reserved.