Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.
Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.
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DOI：
10.2174/1570162x113116660059
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发表时间：
2013-07
影响因子：
1
通讯作者：
Ferrari G
中科院分区：
文献类型：
--
作者：
Pollara J;Bonsignori M;Moody MA;Pazgier M;Haynes BF;Ferrari G
抗体依赖性细胞毒性（ADCC）在控制HIV-1病毒载量和保护机体免受感染中起重要作用。ADCC抗体应答已被映射到HIV-1包膜糖蛋白gp 120和gp 41内的多个线性和构象表位。介导ADCC的抗体靶向的许多表位与能够中和病毒的抗体识别的表位重叠。此外，最近用来自HIV-1感染个体和HIV-1疫苗候选疫苗接种者的人单克隆抗体进行的研究已经鉴定了许多抗体，这些抗体缺乏捕获原代HIV-1分离株或介导中和活性的能力，但能够结合感染的CD 4 + T细胞表面并介导ADCC。值得注意的是，gp 120的构象变化可能不完全与CD 4分子的结合有关，但在暴露ADCC应答识别的表位方面很重要。在这里，我们讨论了ADCC抗体靶向的HIV-1包膜表位的ADCC的潜在保护能力的背景下。
Antibody dependent cellular cytotoxicity [ADCC] has been suggested to play an important role in control of Human Immunodeficiency Virus-1 [HIV-1] viral load and protection from infection. ADCC antibody responses have been mapped to multiple linear and conformational epitopes within the HIV-1 envelope glycoproteins gp120 and gp41. Many epitopes targeted by antibodies that mediate ADCC overlap with those recognized by antibodies capable of virus neutralization. In addition, recent studies conducted with human monoclonal antibodies derived from HIV-1 infected individuals and HIV-1 vaccine-candidate vaccinees have identified a number of antibodies that lack the ability to capture primary HIV-1 isolates or mediate neutralizing activity, but are able to bind to the surface of infected CD4+ T cells and mediate ADCC. Of note, the conformational changes in the gp120 that may not exclusively relate to binding of the CD4 molecule are important in exposing epitopes recognized by ADCC responses. Here we discuss the HIV-1 envelope epitopes targeted by ADCC antibodies in the context of the potential protective capacities of ADCC.
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从人初乳中分离出 HIV-1 中和粘膜单克隆抗体。
影响因子：
3.7
作者：
Friedman J;Alam SM;Shen X;Xia SM;Stewart S;Anasti K;Pollara J;Fouda GG;Yang G;Kelsoe G;Ferrari G;Tomaras GD;Haynes BF;Liao HX;Moody MA;Permar SR
通讯作者：
Permar SR
DOI：
10.1073/pnas.1217609110
发表时间：
2013-01-02
影响因子：
11.1
作者：
Guan, Yongjun;Pazgier, Marzena;Lewis, George K.
通讯作者：
Lewis, George K.
影响因子：
5.4
作者：
Haim, Hillel;Salas, Ignacio;Sodroski, Joseph
通讯作者：
Sodroski, Joseph
DOI：
10.1126/science.1175868
发表时间：
2009-11-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen L;Kwon YD;Zhou T;Wu X;O'Dell S;Cavacini L;Hessell AJ;Pancera M;Tang M;Xu L;Yang ZY;Zhang MY;Arthos J;Burton DR;Dimitrov DS;Nabel GJ;Posner MR;Sodroski J;Wyatt R;Mascola JR;Kwong PD
通讯作者：
Kwong PD
影响因子：
3.3
作者：
Da, Lin-Tai;Quan, Jun-Min;Wu, Yun-Dong
通讯作者：
Wu, Yun-Dong