Fine frequency tuning in monkey auditory cortex and thalamus
Fine frequency tuning in monkey auditory cortex and thalamus
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DOI：
10.1152/jn.00559.2010
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Wang, Xiaoqin
中科院分区：
文献类型：
--
作者：
Bartlett, Edward L.;Sadagopan, Srivatsun;Wang, Xiaoqin
刘晓波，李晓波，李晓波.猴子听觉皮质与视丘的频率微调。J Neurophysiol 106：849-859，2011.首次发表于2011年5月25日; doi：10.1152/jn.00559.2010.-整个上行听觉通路中神经元的频率分辨率对于理解声音是如何处理的很重要。在许多动物实验中，听神经纤维的频率调谐宽度约为1/5倍频程，而听皮层神经元的频率调谐宽度要宽得多。心理物理学研究表明，人类能够区分更细微的频率差异。最近的一项研究表明，这可能归因于人类听觉皮层神经元的频率微调（Bitterman Y，Mukamel R，Malach R，Fried I，Nelken I）。Nature 451：197-201，2008）。我们调查是否这种精细的频率调谐仅限于人类的听觉皮层，通过检查在清醒的普通绒猴的频率调谐宽度。我们发现，27%的神经元在初级听觉皮层表现出频率调谐，比典型的频率调谐的听觉神经和实质上比以前报道的皮质数据从麻醉动物细。在清醒的绒猴中，76%的听觉丘脑神经元也存在精细的频率调谐。频率调谐在持续的反应相比，在听觉皮层神经元的起始反应，但不是在丘脑神经元，表明丘脑皮质或皮质内的动力学形状的时间依赖性的频率调谐在皮层较窄。这些发现挑战的概念，听觉皮层的频率微调是人类听觉皮层所独有的，它是一个从头皮质属性，这表明在以前的动物研究中观察到的更广泛的调谐可能会出现从使用麻醉生理记录或从物种差异。
Bartlett EL, Sadagopan S, Wang X. Fine frequency tuning in monkey auditory cortex and thalamus. J Neurophysiol 106: 849-859, 2011. First published May 25, 2011; doi:10.1152/jn.00559.2010.-The frequency resolution of neurons throughout the ascending auditory pathway is important for understanding how sounds are processed. In many animal studies, the frequency tuning widths are about 1/5th octave wide in auditory nerve fibers and much wider in auditory cortex neurons. Psychophysical studies show that humans are capable of discriminating far finer frequency differences. A recent study suggested that this is perhaps attributable to fine frequency tuning of neurons in human auditory cortex (Bitterman Y, Mukamel R, Malach R, Fried I, Nelken I. Nature 451: 197-201, 2008). We investigated whether such fine frequency tuning was restricted to human auditory cortex by examining the frequency tuning width in the awake common marmoset monkey. We show that 27% of neurons in the primary auditory cortex exhibit frequency tuning that is finer than the typical frequency tuning of the auditory nerve and substantially finer than previously reported cortical data obtained from anesthetized animals. Fine frequency tuning is also present in 76% of neurons of the auditory thalamus in awake marmosets. Frequency tuning was narrower during the sustained response compared to the onset response in auditory cortex neurons but not in thalamic neurons, suggesting that thalamocortical or intracortical dynamics shape time-dependent frequency tuning in cortex. These findings challenge the notion that the fine frequency tuning of auditory cortex is unique to human auditory cortex and that it is a de novo cortical property, suggesting that the broader tuning observed in previous animal studies may arise from the use of anesthesia during physiological recordings or from species differences.