Joint influence of small-effect genetic variants on human longevity.
Joint influence of small-effect genetic variants on human longevity.
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DOI：
10.18632/aging.100191
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发表时间：
2010-09
期刊：
影响因子：
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通讯作者：
Ukraintseva SV
中科院分区：
文献类型：
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作者：
Yashin AI;Wu D;Arbeev KG;Ukraintseva SV
对复杂性状（如寿命或慢性病发病年龄）的全基因组关联研究结果表明，这些性状通常受到大量小效应等位基因的影响。单独地，这些等位基因几乎没有预测价值，因此它们通常被排除在进一步的分析之外。我们的研究结果强烈表明，对寿命有小的个体效应的等位基因可能共同影响寿命，因此产生的影响可能是实质性的和显着的。我们表明，这种联合影响可以用一个相对简单的“遗传剂量-表型反应”关系来描述。
The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be both substantial and significant. We show that this joint influence can be described by a relatively simple “genetic dose - phenotypic response” relationship.