Glycerol release from incubated human adipocytes is not affected by gastrointestinal peptides.
Glycerol release from incubated human adipocytes is not affected by gastrointestinal peptides.
复制标题
孵化的人脂肪细胞释放的甘油不受胃肠道肽的影响。
DOI：
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发表时间：
1985
影响因子：
4.9
通讯作者：
P. Schwandt
中科院分区：
文献类型：
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作者：
W. Richter;P. Schwandt
有证据表明胃肠激素参与肥胖症的发病机制，并有关于动物脂解活性的报道。这些激素的体外脂解活性在人脂肪细胞中进行了测试。血管活性肠多肽、胰高血糖素、促胰液素、人胃泌素I、胃泌素释放多肽、抑胃多肽、胰多肽、胃动素、蛙皮素、神经降压素、C肽以及胆囊收缩素均未刺激脂解作用显著高于基础水平。这些结果表明，这些激素在人肥胖中的参与可能不是由于对人脂肪细胞的直接脂解作用。
There is evidence for involvement of gastrointestinal hormones in pathogenesis of obesity and reports on lipolytic activity in animals. The in vitro lipolytic activity of these hormones was tested in human adipocytes. Vasoactive intestinal polypeptide, glucagon, secretin, human gastrin I, gastrin releasing polypeptide, gastric inhibitory polypeptide, pancreatic polypeptide, motilin, bombesin, neurotensin, C-peptide, as well as cholecystokinin did not stimulate lipolysis significantly above basal. These results indicate that the involvement of these hormones in obesity in man might not be due to a direct lipolytic effect on the human adipocyte.