Secondary EML4-ALK-positive lung adenocarcinoma in a patient previously treated for acute lymphoblastic leukemia in childhood: a case report.
Secondary EML4-ALK-positive lung adenocarcinoma in a patient previously treated for acute lymphoblastic leukemia in childhood: a case report.
复制标题
儿童时期曾接受过急性淋巴细胞白血病治疗的患者继发性 EML4-ALK 阳性肺腺癌：病例报告。
DOI：
10.1093/jjco/hyu028
复制
发表时间：
2014
期刊：
影响因子：
2.4
通讯作者：
Nakamura Y et al.
中科院分区：
文献类型：
--
作者：
清水薫子;辻野一三ほか;Nakamura Y et al.
人们普遍认为，随着儿童期癌症幸存者进入成年期，继发性肿瘤的风险增加。这些主要是血液恶性肿瘤，在这种情况下经常检测到染色体易位。另一方面，虽然继发性上皮恶性肿瘤有时被报道，染色体易位在这些上皮恶性肿瘤没有。一名33岁的男子在大约20年前被诊断出患有急性淋巴细胞白血病并接受化疗，后来被诊断出患有肺腺癌。在该腺癌中检测到棘皮动物微管相关蛋白样4基因和间变性淋巴瘤激酶基因的染色体重排后，他对克唑替尼治疗有反应。因此，我们认为棘皮动物微管相关蛋白样4基因-间变性淋巴瘤激酶基因阳性的肺腺癌是继发性上皮恶性肿瘤。
It is widely recognized that the risk of secondary neoplasms increases as childhood cancer survivors progress through adulthood. These are mainly hematological malignancies, and recurrent chromosome translocations are commonly detected in such cases. On the other hand, while secondary epithelial malignancies have sometimes been reported, chromosome translocations in these epithelial malignancies have not. A 33-year-old man who had been diagnosed with acute lymphoblastic leukemia and treated with chemotherapy almost 20 years earlier was diagnosed with lung adenocarcinoma. After chromosomal rearrangement of echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene was detected in this adenocarcinoma, he responded to treatment with crizotinib. It was therefore concluded that this echinoderm microtubule-associated protein-like 4 gene–anaplastic lymphoma kinase gene-positive lung adenocarcinoma was a secondary epithelial malignancy.