DISPLACEMENT OF SYNAPTIC TERMINALS FROM REGENERATING MOTONEURONS BY MICROGLIAL CELLS
DISPLACEMENT OF SYNAPTIC TERMINALS FROM REGENERATING MOTONEURONS BY MICROGLIAL CELLS
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DOI：
10.1007/bf00325030
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发表时间：
1968-01-01
期刊：
影响因子：
--
通讯作者：
KREUTZBE.G
中科院分区：
文献类型：
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作者：
BLINZING.K;KREUTZBE.G
运动神经元的轴突反应通常伴随着神经元周小胶质细胞的早期活跃增殖。为了阐明这种新形成的小胶质细胞卫星的真实的性质及其与再生神经细胞的精细结构关系，在切断大鼠右侧面神经后4天，通过光学和电子显微镜检查双侧制备的面核。在横切面上，小胶质细胞往往可以观察到紧密相邻的运动神经元胞体和主树突在很长的距离，从而从神经元表面膜去除形态完整的突触末梢。这种位移的小胶质细胞的终扣可能是由一个松散的突触接触，由于一些未知的膜变化再生运动神经元。这个相当大的去传入过程的功能意义无法完全阐明。
Axonal reaction of motoneurons has been shown to be usually accompanied by an early and brisk proliferation of perineuronal microgliacytes. In order to clarify the real nature of such newly formed microglial satellites and their fine structural relationships to the regenerating nerve cells, facial nuclei from bilateral preparations were examined by light and electron microscopy 4 days after cutting the right facial nerve in rats. On the transected side, microgliacytes could often be observed closely adjoining motoneuron perikarya and main dendrites over long distances, and thereby removing morphologically intact synaptic terminals from the neuronal surface membranes. This displacement of boutons by microglial cells is probably preceded by a loosening of the synaptic contacts due to some unknown membrane changes in the regenerating motoneurons. The functional significance of this considerable deafferentation process could not be entirely elucidated.