An epidemiological study of the serum thyrotropin reference range and factors that influence serum thyrotropin levels in iodine sufficient areas of China
An epidemiological study of the serum thyrotropin reference range and factors that influence serum thyrotropin levels in iodine sufficient areas of China
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DOI：
10.1507/endocrj.k11e-101
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发表时间：
2011-11-01
影响因子：
2
通讯作者：
Shan, Zhongyan
中科院分区：
文献类型：
--
作者：
Li, Chenyan;Guan, Haixia;Shan, Zhongyan
本研究于2007年进行，目的是验证国家临床生物化学研究院（NACB）指南提出的选择标准，调查影响促甲状腺激素（TSH）水平的因素，并确定中国碘充足地区血清TSH参考范围。对辽宁省3个碘充足地区的5,348名居民进行了问卷调查，并进行了TSH、TPOAb、TgAb和甲状腺超声检查。正常人TSH呈右偏分布。通常对这些值进行对数变换以观察高斯分布。12-19岁组TSH水平显著高于其他年龄组（p
The aims of this study performed in 2007 were to verify the selection criteria proposed by the National Academy of Clinical Biochemistry (NACB) guidelines, to investigate factors that influence thyrotropin (TSH) levels, and to determine serum TSH reference range in iodine sufficient areas of China. After excluding 291 subjects, a total of 5,348 inhabitants from three iodine sufficient areas of Liaoning province were asked to fulfill the questionnaire, and take TSH, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) measurements and a thyroid ultrasound examination. The distribution of TSH was right skewed in normal people. It has been customary to log transform the values to observe the Gaussian distribution. In the subjects 12-19 years of age, the TSH level was significantly higher than in the other age groups (p