SLG1 plays a role during G1 in the decision to enter or exit the cell cycle.
SLG1 plays a role during G1 in the decision to enter or exit the cell cycle.
复制标题
SLG1 在 G1 期间在决定进入或退出细胞周期中发挥作用。
DOI：
10.1007/pl00008657
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Rose,MD
中科院分区：
文献类型：
--
作者：
Ivanovska,I;Rose,MD
Saccharomyces cerevisiaecells decide to divide during G1. If nutrients are abundant, cells pass through START and coordinately undergo DNA replication, bud emergence, and spindle pole body duplication. Phenotypic analysis of theslg1Δmutant revealed that this mutation uncouples post-START events. At the nonpermissive temperature,slg1Δcells that have undergone bud emergence but not DNA replication or SPB duplication accumulate. Furthermore, while wild-type cells arrest in G0 when starved, theslg1Δmutant fails to arrest at this point; instead, cells with small buds accumulate. Theslg1Δmutation displayed genetic interactions withcdc34, which encodes a regulator of exit from G1. This is consistent with a role ofSLG1in G1 regulation. Epitope-tagged Slg1p cofractionated with the plasma membrane, suggesting that Slg1p may function by integrating external cues and relaying them to the interior of the cell. We propose thatSLG1plays a regulatory role in bud emergence or stationary phase.
