Cockroach sensitivity in Norway: a previously unidentified problem?
Cockroach sensitivity in Norway: a previously unidentified problem?
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DOI：
10.1034/j.1398-9995.2002.13305.x
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发表时间：
2002-06-01
期刊：
影响因子：
12.4
通讯作者：
Mehl, R
中科院分区：
文献类型：
--
作者：
Carlsen, KCL;Carlsen, KH;Mehl, R
背景：人们对斯堪的纳维亚半岛的蟑螂过敏知之甚少，而蟑螂与世界大部分地区的过敏性疾病有关。与国际哮喘遗传学网络 (GAIN) 研究相关，我们报告了挪威对蟑螂的敏感性以及与 IgE 介导的疾病的可能关联。方法：100 个挪威家庭（426 名受试者），其中 7-35 岁患有哮喘的兄弟姐妹及其父母接受了问卷/访谈（医疗和接触史）、对当地常见吸入性过敏原和德国小蠊的皮肤点刺试验 (SPT)，以及 IgE专门针对螨虫、蚊子、虾和蟑螂。如果皮肤点刺试验呈阳性 (≥ 3 mm) 和/或存在 2 类或以上 IgE 抗体，则蟑螂致敏被定义为阳性。结果：31 名受试者 (7.5%) 对蟑螂过敏（5 名单敏）（27 名受试者通过皮肤点刺试验，7 名受试者通过 IgE 抗体，所有受试者均伴有吸入性过敏）。共同过敏最常见的是草（61%）、猫（48%）、狗（48%）和螨虫（42%）。蟑螂过敏受试者报告的过敏性疾病包括哮喘和鼻炎 (n = 10)、仅哮喘 (n = 9)、仅鼻炎 (n = 2) 和既不哮喘又不鼻炎 (n = 10)。结论：由于蟑螂过敏在挪威特应性家族中相对常见，尽管临床意义尚不明确，我们建议患有呼吸道疾病的特应性受试者应考虑蟑螂过敏。
Background: Little is known about cockroach sensitization in Scandinavia, whereas cockroaches are implicated in allergic diseases throughout large parts of the world. In association with the Genetics of Asthma International Network (GAIN) study, we report sensitization to cockroaches and possible association with IgE-mediated diseases in Norway.Methods: 100 Norwegian families (426 subjects) of 7-35-year-old sibling-pairs with asthma and their parents underwent questionnaire/interview (medical and exposure history), skin prick test (SPT) to common local inhalant allergens and German cockroach, and IgE specific to mites, mosquito, shrimp and cockroach. Cockroach sensitization was defined as positive if there was a positive ( ! 3 mm) skin prick test and/or presence of IgE antibody of class 2 or more.Results: Thirty-one subjects (7.5%) were sensitized (five monosensitized) to cockroach (27 by skin prick test and seven by IgE antibody, all with additional inhalant allergy). Co-sensitization was most common to grass (in 61%), cat (48%), dog (48%) and mites (42%). Reported allergic diseases in cockroach-sensitized subjects were asthma and rhinitis (n = 10), asthma only (n = 9), rhinitis only (n = 2) and neither asthma nor rhinitis (n = 10).Conclusions: Since cockroach sensitization was relatively frequent in Norwegian atopic families, albeit with unclear clinical implications, we suggest that cockroach allergy should be considered in atopic subjects with respiratory disease.