Passive catheter tracking during interventional MRI using hyperpolarized 13C
Passive catheter tracking during interventional MRI using hyperpolarized 13C
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DOI：
10.1002/mrm.21239
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发表时间：
2007-06-01
影响因子：
3.3
通讯作者：
Golman, Klaes
中科院分区：
文献类型：
--
作者：
Magnusson, Peter;Johansson, Edvin;Golman, Klaes
MRI中的介入操作可以在临床前使用主动或被动导管跟踪法进行。提出了一种新的无源非质子技术，该技术使用了一种填充了超极化C-13造影剂的导管。建立了一个三腔导管的原型，该导管有两个闭合的管腔，内含流动的超极化C-13造影剂。全长C-13导管可在活体内进行投影显示，导管信噪比接近80，每双投影帧1帧，接近700ms，穿过猪的主动脉时平面内分辨率为2x2 mm(2)。在反投影导管重建和与解剖离线质子路线图进行图像融合后，C-13导管的移动路径被可视化。导管长度可视化由倾斜平面可视化模式辅助。所显示的高导管信号，以及整个导管长度可视化和周围高软组织对比度，值得进一步发展为实时技术。
Interventional procedures in MRI can be performed preclinically using active or passive catheter-tracking methods. A novel passive nonproton technique is suggested that uses a catheter filled with a hyperpolarized C-13 contrast agent. A prototype three-lumen catheter was built with two closed lumens containing a flowing hyperpolarized C-13 contrast agent. Entire-length C-13 catheter projection visualization could be performed in vivo with a catheter SNR of similar to 80, one dual projection frame per similar to 700 ms, and an in-plane resolution of 2 x 2 mm(2) while traveling through the aorta of a pig. The traveling path of the C-13 catheter was visualized after back-projection catheter reconstruction and after image fusion with an anatomical offline proton road map. Catheter length visualization was aided by an oblique planar visualization mode. The high catheter signal demonstrated, together with the entire catheter length visualization and high surrounding soft-tissue contrast, warrants further development into a real-time technique.