Neonatal neurosteroid administration alters parvalbumin expression and neuron number in medial dorsal thalamus of adult rats.
Neonatal neurosteroid administration alters parvalbumin expression and neuron number in medial dorsal thalamus of adult rats.
复制标题
新生神经类固醇给药改变成年大鼠内侧背侧丘脑的小白蛋白表达和神经元数量。
DOI：
10.1016/j.brainres.2004.03.049
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Grobin,AChistina
中科院分区：
文献类型：
--
作者：
Gizerian,SamanthaS;Morrow,ALeslie;Lieberman,JeffreyA;Grobin,AChistina
The neuroactive steroid 3α-hydroxy-5α-pregnane-20-one (allopregnanolone) is a potent endogenous modulator of GABAAreceptor function. A single neonatal allopregnanolone administration (10 mg/kg, i.p.) was previously shown to alter the localization of parvalbumin-positive neurons in the prefrontal cortex at maturity. Cells in the prefrontal cortex receive the majority of their inputs from the medial dorsal nucleus of the thalamus. We investigated whether neonatal allopregnanolone administration alters the neuronal population of the medial dorsal nucleus of the thalamus. We show that the number of parvalbumin-expressing neurons is increased while the total neuron number is decreased in the medial dorsal nucleus after allopregnanolone administration. EAAT3 (excitatory amino acid transporter type 3, the neuron-specific glutamate reuptake transporter) immunoreactivity was unchanged in adjacent sections. These findings suggest that neonatal allopregnanolone administration disrupts the normal development of the prefrontal cortex and medial dorsal thalamus, indicating that neurosteroid levels are important for proper development of thalamocortical systems and may play a role in neurodevelopmental disorders such as schizophrenia.
