The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.
The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.
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发表时间：
1993-07
期刊：
影响因子：
8
通讯作者：
Luca Tamagnone;Juha Partanen;E. Armstrong;Jerzy Lasota;Kinya Ohgami;Tetsushi Tazunoki;S. Laforgia-S.-La
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文献类型：
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作者：
Luca Tamagnone;Juha Partanen;E. Armstrong;Jerzy Lasota;Kinya Ohgami;Tetsushi Tazunoki;S. Laforgia-S.-La
人ryk酪氨酸激酶基因最初是从K562白血病细胞中发现的一段经聚合酶链式反应扩增的基因片段(JTK5)，并被发现代表普遍表达的基因(Partanen et al.，1990)。本文报道的人ryk的开放阅读框编码一种新型的酪氨酸激酶，由607个氨基酸残基组成，具有两个潜在的跨膜结构域，并在其催化区与MET(HGF/SF-R)和IGF-1R等受体酪氨酸激酶同源。该基因定位于人类染色体3Q11-25。3.4kb的ryk基因在所有受检的成人组织中均有表达。
The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino acid residues, having two potential transmembrane domains and homology to receptor tyrosine kinases, such as met (HGF/SF-R) and IGF-1R, in its catalytic domain. The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined.