An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines.
An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines.
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DOI：
10.3389/fphar.2017.00158
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发表时间：
2017
影响因子：
5.6
通讯作者：
Motsinger-Reif AA
中科院分区：
文献类型：
--
作者：
Roell KR;Reif DM;Motsinger-Reif AA
药物和化学品之间的协同相互作用的想法在生物医学界已经是一个重要的问题超过世纪。由于复杂的疾病，特别是癌症，正在用各种药物鸡尾酒治疗，了解这些药物之间的相互作用对于确保成功的治疗方案越来越重要。然而，协同的想法不仅限于生物医学领域，这些想法也在许多不同的学科中发展。在这篇综述中，我们首先讨论了围绕协同概念的各种术语，提供了一个跨众多学科定义的术语的全面列表。然后，我们审查了最常见的方法检测和量化的协同作用，包括两个最突出的参考模型描述添加剂的相互作用：Loewe加性和布利斯独立。我们还讨论了每种方法的优点和局限性，重点是Chou-Talalay组合指数法。最后，我们描述了方法的发展和术语是如何在生物医学和药理学之外的学科中发展起来的，以便为读者综合文献。
The idea of synergistic interactions between drugs and chemicals has been an important issue in the biomedical world for over a century. As complex diseases, especially cancer, are being treated with various drug cocktails, understanding the interactions among these drugs is increasingly vital to ensuring successful treatment regimens. However, the idea of synergy is not limited to only the biomedical realm and these ideas have developed across many different disciplines, as well. In this review, we first discuss the various terminology surrounding the idea of synergy, providing a comprehensive list of terms defined across numerous disciplines. We then review the most common methodology for detection and quantification of synergy, including the two most prominent reference models for describing additive interactions: Loewe Additivity and Bliss Independence. We also discuss advantages and limitations to each method, with a focus on the Chou-Talalay Combination Index method. Finally, we describe how methods development and terminology have developed among disciplines outside of biomedicine and pharmacology, to synthesize the literature for readers.