Effects of two antihistamine drugs on actual driving performance.
Effects of two antihistamine drugs on actual driving performance.
复制标题
两种抗组胺药物对实际驾驶性能的影响。
作者：
T. Betts;D. Markman;S. Debenham;D. Mortiboy;T. McKevitt
进行了一项双盲安慰剂对照实验，测量中枢活性抗组胺药曲普立啶和外周活性抗组胺药特非那定对一组经验丰富的女驾驶员实际驾驶表现的影响。曲普立定极大地损害了驾驶行为，而特非那定却没有。曲普立定还会损害情绪和唤醒的主观和客观测量，尽管意识到服用这种药物时驾驶受到损害，但受试者无法纠正他们的表现。这项研究表明，需要抗组胺药物的驾驶员应避免使用中枢性药物。
A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures of mood and arousal, and despite an awareness that their driving was impaired while they were taking this agent subjects could not correct their performance. This study suggests that drivers who need antihistamine drugs should avoid those that act centrally.