2ND MALIGNANT NEOPLASMS IN PATIENTS WITH HEAD AND NECK SQUAMOUS-CELL CARCINOMAS
2ND MALIGNANT NEOPLASMS IN PATIENTS WITH HEAD AND NECK SQUAMOUS-CELL CARCINOMAS
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DOI：
10.3109/02841869309093596
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发表时间：
1993-01-01
期刊：
影响因子：
3.1
通讯作者：
LOVEN, JO
中科院分区：
文献类型：
--
作者：
BOYSEN, M;LOVEN, JO
分析714例口腔、口咽部、下咽和喉部鳞状细胞癌的二次恶性肿瘤（SMN）发生率。最小随访时间为3.5年，风险为2540人年，81例患者发生84例SMN（10例同步，74例非同步）。SMN的相对危险度为2.4。精算方法显示SMN的年发生率为3.5%。口腔和口咽肿瘤SMN的年发病率分别为4.0%和3.8%，喉癌为2.1% （p < 0.013和0.017）。性别、年龄和肿瘤分期对SMN的年发病率无显著影响。经过3年的随访，SMN比局部-区域复发更令人担忧。
The incidence of second malignant neoplasms (SMN) was analyzed in 714 patients with squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx and larynx. With a minimum follow-up of 3.5 years and 2 540 person-years at risk 84 SMN (10 synchronous and 74 metachronous) developed in 81 patients. The relative risk of SMN was 2.4. The actuarial method showed an annual incidence of SMN of 3.5%. For oral cavity and oropharyngeal tumors the annual incidence of SMN was 4.0% and 3.8% respectively, compared to 2.1% for laryngeal cancer (p < 0.013 and 0.017 respectively). Sex, age or stage of the index tumor did not significantly influence the annual incidence of SMN. After 3 years of follow-up, SMN became more a cause of concern than loco-regional relapse.