Facile Amidogen Bio-Activation Method Can Boost the Soft Tissue Integration on 3D Printed Poly-Ether-Ether-Ketone Interface
Facile Amidogen Bio-Activation Method Can Boost the Soft Tissue Integration on 3D Printed Poly-Ether-Ether-Ketone Interface
复制标题
简单的酰胺生物激活方法可以促进 3D 打印聚醚醚酮界面上的软组织整合
DOI：
10.1002/admi.202100547
复制
发表时间：
2021-09-09
影响因子：
5.4
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Liu, Xi;Huang, Lijun;Wang, Lei
Poly-ether-ether-ketone (PEEK) implants with good mechanical properties and chemical inertia, meet the urgent needs of bone substitute. However, its inert interface leads to poor soft tissue integration, which prolongs healing time of surgical incision with many complications. Herein, (3-aminopropyl) triethoxysilane is connected to 3D printed (3DP) PEEK interface by chemical modification. The homogeneous amino groups on amidogen interface enhance PEEK's hydrophilicity and proteinophilia significantly. Fibroblasts cultured on the amidogen PEEK interface show much stronger potential of cell adhesion and migration. Furthermore, soft tissue ingrowth into 3DP PEEK scaffold occurs more and faster in the amidogen interface in vivo. The observation of the microstructure shows tighter implant-tissue bonding interfaces on the amidogen PEEK. To mimic real surgery, 3DP PEEK implants of the same proportions in clinical practice are used to reconstruct the chest wall defects of rabbits. A significant reduction in healing time and incision complications are observed in the amidogen PEEK groups. In addition, 19 related proteins are found in the fibroblasts cultured on the amidogen PEEK interface, which can be used to trace the biological mechanisms. In all, the facile amidogen bio-activation method can significantly boost the soft tissue integration on 3DP PEEK interface with less surgical complications.
