Poly(fumaric-co-sebacic anhydride) - A degradation study as evaluated by FTIR, DSC, GPC and X-ray diffraction
Poly(fumaric-co-sebacic anhydride) - A degradation study as evaluated by FTIR, DSC, GPC and X-ray diffraction
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DOI：
10.1016/s0168-3659(99)00016-4
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发表时间：
1999-06-28
影响因子：
10.8
通讯作者：
Mathiowitz, E
中科院分区：
文献类型：
--
作者：
Santos, CA;Freedman, BD;Mathiowitz, E
三个聚（己二酸-共-癸二酸酐）[P（FA：SA）]共聚物的降解在由热熔封装工艺制成的微球组合物中进行检查。低分子量低聚物的出现发生在共聚物微球的降解过程中，通过各种表征方法证明。采用傅里叶变换红外光谱（FTIR）、凝胶渗透色谱（GPC）、差示扫描量热法（DSC）和X射线衍射（XRD）对聚酸酐微球的降解程度进行了表征。结果表明，P（FA：SA）的降解大大加快在碱性pH值，但在中性和酸性缓冲液中的降解之间的差异不大。每种表征方法的结果之间存在良好的相关性，这使得更好地理解降解过程和由此形成的低分子量低聚物聚（癸二酸酐-共-癸二酸酐）。(C)1999 Elsevier Science B. V.保留所有权利。
The degradation of three poly(fumaric-co-sebacic anhydride) [P(FA:SA)] copolymers is examined in a composition of microspheres made by the hot melt encapsulation process. The emergence of low molecular weight oligomers occurs during degradation of the copolymer microspheres, as evidenced by a variety of characterization methods. Characterization was conducted to determine the extent of degradation of the polyanhydride microspheres using Fourier-transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and X-ray diffraction. It is demonstrated that degradation of P(FA:SA) is greatly accelerated at basic pH, yet there is little difference between degradation in neutral and acidic buffers. A good correlation exists between the results of each characterization method, which allows a better understanding of the degradation process and the resulting formation of low molecular weight oligomers in poly(fumaric-co-sebacic anhydride). (C) 1999 Elsevier Science B.V. All rights reserved.