Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging
Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging
复制标题
用于磁共振成像的水溶性超顺磁性铁酸锰纳米粒子
DOI：
10.1016/j.biomaterials.2010.01.055
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发表时间：
2010-05-01
期刊：
影响因子：
14
通讯作者：
Yang, Shiping
中科院分区：
文献类型：
--
作者：
Yang, Hong;Zhang, Cuixia;Yang, Shiping
我们在这里报告的热分解方法合成的水溶性超顺磁性锰铁氧体（MnFe 2 O 4）纳米粒子（NP）的磁共振（MR）成像应用。在这种方法中，四甘醇被用作配位和稳定剂，使纳米粒子的水溶性和稳定。所形成的NP具有7 nm的直径和窄的尺寸分布，并且是超顺磁性的，饱和磁化强度（Ms）为39 emu/g。体外细胞毒性试验表明，MnFe 2 O 4纳米颗粒在低于200 μ g/mL的颗粒浓度下具有生物相容性。基于铁浓度，孵育后MnFe 2 O 4纳米颗粒在水和细胞中的横向弛豫率分别测定为189.3 mM（-1）s（-1）和36.8 mM（-1）s（-1）。在体内MR成像研究结合电感耦合等离子体原子发射光谱显示，静脉注射后4小时，MnFe 2 O 4纳米颗粒优先在肝脏中积累。这表明所开发的MnFe 2 O 4 NPs可以用作用于肝脏成像的灵敏的MR成像造影剂。通过适当地修饰或功能化纳米颗粒的表面，这些颗粒可以用于其他疾病的MR检测。皇冠版权所有（C）2010由爱思唯尔有限公司出版。保留所有权利。
We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe2O4) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs water-soluble and stable. The formed NPs had a diameter of 7 nm with a narrow size distribution, and were superparamagnetic with a saturated magnetization (Ms) of 39 emu/g. In vitro cytotoxicity test revealed that the MnFe2O4 NPs were biocompatible at a particle concentration below 200 mu g/mL The transverse relaxivity of MnFe2O4 NPs in water and cells after incubation were determined to be 189.3 mM(-1) s(-1) and 36.8 mM(-1) s(-1) based on iron concentration, respectively. In vivo MR imaging studies in conjunction with inductively coupled plasma-atomic emission spectroscopy showed that the MnFe2O4 NPs were preferentially accumulated in liver after intravenous injection for 4 h. This suggests that the developed MnFe2O4 NPs can serve as a sensitive MR imaging contrast agent for liver imaging. By appropriately modifying or functionalizing the surface of the NPs, these particles may be used for MR detection of other diseases. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.