Use of functional imaging to monitor central control of voiding in humans.
Use of functional imaging to monitor central control of voiding in humans.
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DOI：
10.1007/978-3-642-16499-6_5
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发表时间：
2011-01-01
影响因子：
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通讯作者：
Griffiths, Derek J
中科院分区：
文献类型：
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作者：
Griffiths, Derek J
膀胱问题往往是控制障碍，这是从大脑行使。在这种疾病中，大脑对膀胱事件的反应是异常的;治疗伴随着区域变化，这些变化可以通过功能成像来测量，并用于监测治疗效果。区域响应可以根据膀胱控制系统的试验模型来理解。该模型还有助于解释当来自膀胱或尿道的传入信号通过实验或潜在疾病或治疗（例如膀胱过度活动症（急迫性/紧迫性尿失禁））发生变化时，大脑行为（如功能扫描成像）的变化。成功的治疗可能会提高科普问题的能力，也可能具有治愈作用。治疗引起的异常脑反应变化的方向可以区分这两种可能性，并阐明治疗机制。此外，大脑活动的区域，如大脑皮层或背侧前扣带皮层可以被视为代理的感觉，如愿望排尿或紧迫感，这是难以界定或测量。监测这些区域的大脑反应提供了一种明显的方法来测试药物的效果。
Bladder problems are frequently disorders of control, which is exercised from the brain. In such disorders, brain responses to bladder events are abnormal; therapy is accompanied by regional changes that may be measured by functional imaging and used to monitor the effect of treatment. The regional responses may be understood in terms of a tentative model of the bladder control system. The model helps also to interpret alterations in brain behavior (as imaged by functional scanning) that occur when afferent signals from bladder or urethra are changed experimentally or by an underlying disorder or treatment, for example, overactive bladder (urge/urgency incontinence). Successful treatment may either increase the ability to cope with the problem or may be curative. The direction of treatment-induced change of abnormal brain responses can distinguish these two possibilities and shed light on the therapeutic mechanism. In addition, brain activity in regions such as insula or dorsal anterior cingulate cortex may be regarded as a proxy for sensations such as desire to void or urgency, which are otherwise difficult to define or measure. Monitoring of brain responses in these regions offers an obvious way to test the effect of drugs.