Tissue-specific clocks in Arabidopsis show asymmetric coupling.
Tissue-specific clocks in Arabidopsis show asymmetric coupling.
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DOI：
10.1038/nature13919
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发表时间：
2014-11-20
期刊：
影响因子：
64.8
通讯作者：
Kay, Steve A.
中科院分区：
文献类型：
--
作者：
Endo, Motomu;Shimizu, Hanako;Nohales, Maria A.;Araki, Takashi;Kay, Steve A.
许多生物依靠生物钟系统来适应日常和季节性的环境变化。哺乳动物的昼夜节律钟由位于视交叉上核的一个中心时钟组成，该中心时钟与周围组织中的其他时钟紧密耦合。植物也有生物钟，但植物生物钟功能一直被认为是解耦的。只有少数研究能够显示细胞之间的弱局部耦合。在这里，通过实施两种新的技术，我们已经进行了全面的叶组织的组织特异性分析，我们已经发现，在拟南芥中的脉管系统和叶肉时钟不对称地相互调节。脉管系统中的生物钟具有不同于其他组织的特征，在没有环境线索的情况下稳健地循环，并且影响其他组织中的生物钟调节。此外，我们发现，富含血管的基因是有节奏的，优先在晚上表达，而有节奏的叶肉富集基因往往在早上表达。我们的研究结果为更深入地了解植物中的脉管生物钟如何调节开花时间等关键生理反应奠定了基础。
Many organisms rely on a circadian clock system to adapt to daily and seasonal environmental changes. The mammalian circadian clock consists of a central clock in the suprachiasmatic nucleus that is tightly coupled and synchronizes other clocks in peripheral tissues. Plants also have a circadian clock, but plant circadian clock function has long been assumed to be uncoupled. Only a few studies have been able to show a weak, local coupling among cells. Here, by implementing two novel techniques, we have performed a comprehensive tissue-specific analysis of leaf tissues, and we have discovered that the vasculature and mesophyll clocks asymmetrically regulate each other in Arabidopsis. The circadian clock in the vasculature has characteristics distinct from other tissues, cycles robustly without environmental cues, and affects circadian clock regulation in other tissues. Furthermore, we found that vasculature-enriched genes that are rhythmic are preferentially expressed in the evening, whereas rhythmic mesophyll-enriched genes tend to be expressed in the morning. Our results set the stage for a deeper understanding of how the vasculature circadian clock in plants regulates key physiological responses such as flowering time.
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