Association of complete recovery from acute kidney injury with incident CKD stage 3 and all-cause mortality.
Association of complete recovery from acute kidney injury with incident CKD stage 3 and all-cause mortality.
复制标题
DOI：
10.1053/j.ajkd.2012.03.014
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Chonchol M
中科院分区：
文献类型：
--
作者：
Jones J;Holmen J;De Graauw J;Jovanovich A;Thornton S;Chonchol M
对于急性肾损伤 (AKI) 发作后肾功能完全恢复的患者的长期结局，目前存在知识空白。我们试图确定 AKI 发作后肾功能的完全恢复是否与基线肾功能正常的患者发生 3 期慢性肾病 (CKD) 和死亡率相关。回顾性队列研究。来自综合医疗服务系统的 3,809 名患者在 1999 年 1 月 1 日至 2009 年 12 月 31 日期间住院，并随访至 2010 年 3 月 31 日。AKI 由 ICD-9 代码定义并使用急性肾损伤网络 (AKIN) 定义，完全康复定义为血清肌酐降低至基线值的 1.10 倍以下。事件 3 期 CKD 持续 3 个月和全因死亡率。中位随访 2.5 年后，有 AKI 和无 AKI 的患者中，发生 3 期 CKD 的比例分别为 15% 和 3%，在倾向评分分层分析中，未经调整的 HR 为 5.93（95% CI，4.49-7.84），HR 为 3.82（95% CI，2.81-5.19）。患有和不患有 AKI 的患者的死亡人数分别为 35% 和 24%，未经调整的 HR 为 1.46（95% CI，1.27-1.68）。在倾向评分分层分析中，HR 降至 1.08（95% CI，0.93-1.27）。无法测量白蛋白尿。对于基线肾功能正常的受试者，AKI 发作后肾功能的完全恢复与发生 3 期 CKD 的风险增加相关，但与全因死亡率无关。
There is a gap of knowledge in the long-term outcomes of patients who have complete recovery of kidney function after an episode of acute kidney injury (AKI). We sought to determine if complete recovery of kidney function after an episode of AKI is associated with development of incident stage 3 chronic kidney disease (CKD) and mortality in patients with normal baseline kidney function. Retrospective cohort study. 3,809 patients from an integrated healthcare delivery system that had a hospitalization between January 1, 1999 and December 31, 2009 with follow-up through March 31, 2010. AKI defined by ICD-9 codes and using the Acute Kidney Injury Network (AKIN) definition with complete recovery defined by reduction in serum creatinine to less than 1.10 times the baseline value. Incident stage 3 CKD persistent for 3 months and all-cause mortality. After a median follow-up of 2.5 years, incident stage 3 CKD occurred in 15% and 3% of those with and without AKI, respectively, with an unadjusted HR of 5.93 (95% CI, 4.49-7.84) and a HR of 3.82 (95% CI, 2.81-5.19) in propensity score-stratified analyses. Deaths occurred in 35% and 24% of those with and without AKI, respectively, with an unadjusted HR of 1.46 (95% CI, 1.27-1.68). In the propensity score stratified analyses, HR decreased to 1.08 (95% CI, 0.93-1.27). Measurements of albuminuria were not available. Complete recovery of kidney function after an episode of AKI in subjects with normal baseline kidney function is associated with an increased risk of development of incident stage 3 CKD but not all-cause mortality.
登录
查看更多内容
影响因子：
2
作者：
Austin, Peter C.
通讯作者：
Austin, Peter C.
影响因子：
37.8
作者：
D'Agostino, Ralph B., Jr.
通讯作者：
D'Agostino, Ralph B., Jr.
影响因子：
38.9
作者：
de Mendonça, A;Vincent, JL;Cantraine, F
通讯作者：
Cantraine, F
影响因子：
13.6
作者：
Ishani, Areef;Xue, Jay L.;Collins, Allan J.
通讯作者：
Collins, Allan J.
影响因子：
39.2
作者：
Levey, Andrew S.;Coresh, Josef;Van Lente, Frederick
通讯作者：
Van Lente, Frederick