pH-sensitive liposomes: mechanism of triggered release to drug and gene delivery prospects.
pH-sensitive liposomes: mechanism of triggered release to drug and gene delivery prospects.
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发表时间：
2002-10
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通讯作者：
P. Venugopalan;Sanyog Jain;S. Sankar;Paramjit Singh;Amit Rawat;S. P. Vyas
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作者：
P. Venugopalan;Sanyog Jain;S. Sankar;Paramjit Singh;Amit Rawat;S. P. Vyas
越来越多的文献描述了新的靶向和/或释放触发方案的开发和应用，以提高封装在脂质体中的药物的治疗指数。可以改变脂质体系统的组成以促进响应于环境条件的位点特异性释放，即在大体解剖学水平、在细胞或亚细胞水平。它们被设计为响应内体系统内的酸性pH释放其内容物，同时在血浆中保持稳定，从而改善各种极性物质和大分子如抗肿瘤药物、毒素、蛋白质和DNA的细胞质递送。本文综述了pH敏感脂质体的研究进展。
A growing amount of literature describes the development and applications of novel targeting and/or release triggering schemes to improve the therapeutic index of drugs encapsulated within liposomes. The composition of liposomal systems can be modified to facilitate site specific release in response to environmental conditions, namely at the gross anatomical level, at the cellular or sub-cellular level. They are designed in order to release their contents in response to acidic pH within the endosomal system while remaining stable in plasma thus improving the cytoplasmic delivery of various polar materials and macromolecules such as anti-tumor drugs, toxins, proteins and DNA. This review covers various aspect of research on pH-sensitive liposomes.