Exposure to myelotoxic agents and myelodysplasia: case-control study and correlation with clinicobiological findings
Exposure to myelotoxic agents and myelodysplasia: case-control study and correlation with clinicobiological findings
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DOI：
10.1046/j.1365-2141.1998.00963.x
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发表时间：
1998-10-01
影响因子：
6.5
通讯作者：
Castoldi, G
中科院分区：
文献类型：
--
作者：
Rigolin, GM;Cuneo, A;Castoldi, G
为了更好地确定骨髓毒性药物暴露在骨髓增生异常综合征（MDS）发生中的作用，我们进行了(a)一项病例对照研究，以确定发生MDS的相对风险（RR），包括178名连续患者和178名性别和年龄匹配的对照组；(b)对职业暴露于骨髓毒性物质后发生的MDS和“未暴露”患者发生MDS的临床生物学特征的研究。“暴露”状态的定义基于预先确定的问卷，并计算“暴露”指数（小时/天x天/年x年）。在48例和25例MDS患者中分别记录了累积暴露于农药或有机溶剂的时间为bbbb2400小时，而对照为27例和4例
To better define the role of exposure to myelotoxic agents in the genesis of myelodysplastic syndrome (MDS), we carried out (a) a case-control study for the determination of the relative risk (RR) of developing MDS, including 178 consecutive patients and 178 sex- and age-matched controls; (b) a study of clinicobiological features in MDS arising after occupational exposure to myelotoxic agents and in MDS in 'non-exposed' patients, The definition of the 'exposure' status was based on a predetermined questionnaire, with calculation of an 'exposure' index (hours/ day x days/year x years). Cumulative exposure to pesticides or to organic solvents, for >2400 h, was recorded in 48 and 25 MDS patients, respectively, compared to 27 and four controls (P