Stereotactic body radiation therapy and intensity modulated radiation therapy induce different plasmatic cytokine changes in non-small cell lung cancer patients: a pilot study
Stereotactic body radiation therapy and intensity modulated radiation therapy induce different plasmatic cytokine changes in non-small cell lung cancer patients: a pilot study
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DOI：
10.1007/s12094-015-1473-x
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发表时间：
2016-10-01
影响因子：
3.4
通讯作者：
Ricardi, U.
中科院分区：
文献类型：
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作者：
Trovo, M.;Giaj-Levra, N.;Ricardi, U.
为探讨局部晚期和早期非小细胞肺癌(NSCLC)放射治疗过程中血浆细胞因子的动态变化，对15例早期非小细胞肺癌(NSCLC)采用立体定向体部放疗(SBRT)至极低分割放疗(52Gy8次)，13例局部晚期非小细胞肺癌(NSCLC)采用调强适形放疗(IMRT)至根治性适度低分割(60Gy25次)。SBRT组于SBRT后第1天(TFD)、最后一天(TLD)和结束后45d(T45d)采集外周血。对于接受调强放射治疗的患者，分别在TFD、2周(T2w)、4周(T4w)、TLD和T45d采集血样。检测IL-1、IL-1ra、IL-2、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IL-12、IL-13、IL-15、IL-17A、EGF、成纤维细胞生长因子2、干扰素-γ、MIP-1α、MIP-1β、转化生长因子-α、肿瘤坏死因子-α和血管内皮生长因子。细胞因子水平的测量在不同的放疗时间和比较。没有记录的基线水平的细胞因子水平的患者放射治疗方法(除MIP-1α)。对于SBRT患者，TLD和TFD患者的血浆IL-10和IL-17水平分别平均降低(p<；0.05)。对于调强放疗患者，T4w和TFD患者血浆中IL-1、IL-1ra、IL-2、IL-12、成纤维细胞生长因子-2、MIP-1α、MIP-1β、转化生长因子-α、肿瘤坏死因子-α、血管内皮生长因子水平的平均降低有统计学意义(p<；0.05)。SBRT和IMRT在非小细胞肺癌患者中诱导不同的血浆细胞因子变化，支持放疗方案和技术对宿主免疫反应有不同影响的假设。
To assess kinetics of plasmatic cytokines during radiation therapy (RT) for locally advanced and early-stage non-small cell lung cancer (NSCLC).This prospective study was conducted on 15 early-stage NSCLC underwent to extreme hypofractionated regimen (52 Gy in 8 fractions) with stereotactic body RT (SBRT), and 13 locally advanced NSCLC underwent to radical moderated hypofractionated regimen (60 Gy in 25 fractions) with intensity modulated RT (IMRT). For patients undergoing SBRT, peripheral blood samples were collected on the first day of SBRT (TFd), the last day (TLd) and 45 days (T45d) after the end of SBRT. For patients undergoing IMRT, blood samples were collected at: TFd, 2 weeks (T2w), 4 weeks (T4w), TLd, and T45d. The following cytokines were measured: IL-1, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17A, EGF, FGF-2, INF-gamma, MIP-1 alpha, MIP-1 beta, TGF-alpha, TNF-alpha, and VEGF. Cytokine levels measured in different RT time and compared.No difference in baseline levels of cytokines was documented between patient radiation approaches (except for MIP-1 alpha). For SBRT patients, a mean reduction of IL-10 and IL-17 plasma level was documented between TLd and TFd, respectively (p < 0.05). For IMRT patients, a statistically significant (p < 0.05) mean plasma level reduction was documented between T4w and TFd for all the following cytokines: IL-1, IL-1ra, IL-2, IL-12, FGF-2, MIP-1 alpha, MIP-1 beta, TGF-alpha, TNF-alpha, VEGF.SBRT and IMRT induce different plasmatic cytokine changes in NSCLC patients, supporting hypothesis that RT regimes of dose schedules and techniques have different impacts on the host immune response.