Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation
Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation
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DOI：
10.1523/jneurosci.16-01-00392.1996
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发表时间：
1996-01-01
影响因子：
5.3
通讯作者：
Contreras, D
中科院分区：
文献类型：
--
作者：
Steriade, M;Amzica, F;Contreras, D
我们研究了同步的快速自发振荡（主要是30-40赫兹）在麻醉和行为猫的同时从多个新皮层区域的细胞外和细胞内记录。快速傅立叶变换，自相关和互相关，以及尖峰或波触发的平均值被用来确定快速振荡的频率和时间相干性，这些振荡持续时间超过了上行激活系统的刺激，或者在清醒和快速眼动（REM）睡眠的行为状态期间自然发生，但也出现在缓慢睡眠振荡的去极化阶段。在90%的微电极轨迹中，快速振荡在皮质的任何深度都没有显示出场反转，并且在底层的白色物质中也观察不到。快速振荡的负场电位在所有深度与神经元放电相关。快速振荡的这种场电位特性与缓慢睡眠振荡或诱发电位在0.25-0.5 mm深度的逆转形成鲜明对比。快速自发节律的连贯性在空间上是有限的，被限制在一个皮质柱酸之间紧密定位的新皮质部位，与长距离同步的缓慢睡眠节律相反。去极化电流脉冲引起以30-40 Hz的频率重复的尖峰-爆发（200-400 Hz）。我们的实验表明，一个完全deserminized皮层活动的传统观念唤醒时，应修订为快节奏的增强和同步在大脑激活过程中的皮层内网络。自发发生的阈下膜电位去极化振荡可能使皮层和丘脑神经元以快频率同步响应清醒状态下的相关刺激或REM睡眠中内部产生的驱动。
We investigated the synchronization of fast spontaneous oscillations (mainly 30-40 Hz) in anesthetized and behaving cats by means of simultaneous extra- and intracellular recordings from multiple neocortical areas. Fast Fourier transforms, auto- and cross-correlations, and spike- or wave-triggered averages were used to determine the frequency and temporal coherence of fast oscillations that outlasted the stimulation of ascending activating systems or that occurred naturally during behavioral states of waking and rapid eye movement (REM) sleep but also appeared during the depolarizing phases of slow sleep oscillations. In 90% of microelectrode tracks, the fast oscillations did not show field reversal at any depth of the cortex and were not observable in the underlying white matter. The negative field potentials of the fast oscillations were associated at all depths with neuronal firing. This field potential property of fast oscillations was in sharp contrast to the reversal of slow sleep oscillation or evoked potentials at depths of 0.25-0.5 mm. The coherence of fast spontaneous rhythms was spatially limited, being confined within a cortical column acid among closely located neocortical sites, in contrast to the long-range synchronization of slow sleep rhythms. Depolarizing current pulses elicited spike-bursts (200-400 Hz) recurring at a frequency of 30-40 Hz. Our experiments demonstrate that the conventional notion of a totally desynchronized cortical activity upon arousal should be revised as fast rhythms are enhanced and synchronized within intracortical networks during brain activation. Spontaneously occurring, subthreshold membrane potential depolarizing oscillations may bias cortical and thalamic neurons to respond synchronously, at fast frequencies, to relevant stimuli in the wake state or to internally generated drives in REM sleep.