Pathological features of virus infections of the central nervous system (CNS) in the acquired immunodeficiency syndrome (AIDS).
Pathological features of virus infections of the central nervous system (CNS) in the acquired immunodeficiency syndrome (AIDS).
复制标题
获得性免疫缺陷综合症（艾滋病）中枢神经系统（CNS）病毒感染的病理特征。
DOI：
10.1111/j.1440-1827.1991.tb01644.x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Nagashima,K
中科院分区：
文献类型：
--
作者：
Hall,WW;Farmer,PM;Takahashi,H;Tanaka,S;Furuta,Y;Nagashima,K
神经系统疾病是获得性免疫缺陷综合征（艾滋病）发病和死亡的常见原因。在本报告中，我们描述了与人类免疫缺陷病毒（HIV）感染和艾滋病中主要的机会性病毒感染，巨细胞病毒（CMV）， JC乳头状病毒（JCV）和单纯疱疹病毒（HSV）相关的神经病理改变。此外，在每种情况下，“原位”杂交研究已被用于检测病毒基因组物质，并证明了这种方法在支持病理诊断方面的实用性。机制，其中艾滋病毒感染导致白质脑病和可能的贡献作用的三种机会性病毒感染进行了讨论。
Neurological disorders are a common cause of morbidity and mortality in the acquired immunodeficiency syndrome (AIDS). In this report we describe the neuropathological changes associated with both human immunodeficiency virus (HIV) infection and with the major opportunistic virus infections, cytomegalovirus (CMV), JC papovavirus (JCV) and herpes simplex virus (HSV) seen in AIDS. In addition“in situ”hybridization studies have been employed for the detection of virus genomic material in each case and the usefulness of this method in supporting the pathological diagnosis is demonstrated. Mechanisms whereby HIV infection results in leukoencephaiopathy and the possible contributing roles of the three opportunistic virus infections are discussed.