Synthesis and Structure Determination of (2S, 2′S)-3-Phenyl-2-(pyrrolidin-2′-yl)- propionic Acid
Synthesis and Structure Determination of (2S, 2′S)-3-Phenyl-2-(pyrrolidin-2′-yl)- propionic Acid
复制标题
(2S,2′S)-3-苯基-2-(吡咯烷-2′-基)-丙酸的合成及结构测定
DOI：
10.1081/scc-120026314
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发表时间：
2003
影响因子：
2.1
通讯作者：
Tian Guan Rong
中科院分区：
文献类型：
--
作者：
Jin Jing Yi;Zheng Ming Hua;Tian Guan Rong
摘要以L-脯氨酸为起始原料，合成了β-2，β-3-高氨酸衍生物(2S，2‘-S)-3-苯基-2-(吡咯烷基-2’-基)丙酸。在温和条件下制备(4S，4aS)-4-benzyl-4a，5，6，7-tetrahydro-pyrrolo-[1，2-c]pyrimidine-1，3-dione)后，用2DH-HCOSY和H-HNOESY技术对目标化合物的绝对构型进行了指认。
Abstract Aβ2,β3-homoproline derivative, (2S, 2′S)-3-phenyl-2-(pyrrolidin-2′-yl)propionic acid, was synthesized starting from l-proline. After preparation of the (4S, 4aS)-4-benzyl-4a,5,6,7-tetrahydro-pyrrolo-[1,2-c]pyrimidine-1,3-dione under a mild condition, the absolute configuration of target compound was assigned using 2D H-H COSY and H-H NOESY technologies.