Traveling and standing waves mediate pattern formation in cellular protrusions
Traveling and standing waves mediate pattern formation in cellular protrusions
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DOI：
10.1126/sciadv.aay7682
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发表时间：
2020-08-01
期刊：
影响因子：
13.6
通讯作者：
Iglesias, Pablo A.
中科院分区：
文献类型：
--
作者：
Bhattacharya, Sayak;Banerjee, Tatsat;Iglesias, Pablo A.
变形虫迁移过程中调节突起的机制表现出兴奋性。理论研究表明，可激发系统中行波和驻波可能共存。在这里，我们演示了行波到驻波的直接转换，并为这种转换的稳定性建立了条件。该理论结合了可激发波停止和零速度驻波家族的出现，而不改变扩散参数。通过实验，我们证明了这种现象在一些盘基网柄菌和哺乳动物突变株的细胞皮层上的存在。我们进一步预测了一个包含一系列突出表型的模板，包括伪足和丝状伪足，通过行波和驻波之间的转换，允许细胞在兴奋性和双稳态之间切换。总的来说，这表明一种以前未识别的模式形成方法控制着细胞的运动，其中行波传播、停止并变成驻波，然后重新排列形成稳定的模式。
The mechanisms regulating protrusions during amoeboid migration exhibit excitability. Theoretical studies have suggested the possible coexistence of traveling and standing waves in excitable systems. Here, we demonstrate the direct transformation of a traveling into a standing wave and establish conditions for the stability of this conversion. This theory combines excitable wave stopping and the emergence of a family of standing waves at zero velocity, without altering diffusion parameters. Experimentally, we show the existence of this phenomenon on the cell cortex of some Dictyostelium and mammalian mutant strains. We further predict a template that encompasses a spectrum of protrusive phenotypes, including pseudopodia and filopodia, through transitions between traveling and standing waves, allowing the cell to switch between excitability and bistability. Overall, this suggests that a previously-unidentified method of pattern formation, in which traveling waves spread, stop, and turn into standing waves that rearrange to form stable patterns, governs cell motility.