IDENTIFICATION AND INTERPRETATION OF EPIDERMAL GROWTH-FACTOR AND C-ERBB-2 OVEREXPRESSION
IDENTIFICATION AND INTERPRETATION OF EPIDERMAL GROWTH-FACTOR AND C-ERBB-2 OVEREXPRESSION
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DOI：
10.1016/0959-8049(92)90429-6
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发表时间：
1992-01-01
影响因子：
8.4
通讯作者：
GUSTERSON, BA
中科院分区：
文献类型：
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作者：
GUSTERSON, BA
正常细胞基因的过表达可能是恶性细胞获得选择性生长优势的机制之一。 表皮生长因子受体和c-erbB-2蛋白是erbB家族的成员，是通过这种机制发挥作用的基因的很好例子。 对这两种蛋白质的分子和生物化学分析也说明了对生长因子、生长因子受体和致癌逆转录病毒的研究如何可能导致诊断和治疗的新方法。 特别是，这些生长因子受体的过表达已经确定了可能对化疗反应不同的临床亚组，并为抗体靶向治疗提供了机会。 这些蛋白质的过表达可以使用免疫细胞化学在组织切片和细针抽吸物上进行鉴定，从而使这些参数能够在术前进行评估并在治疗期间进行监测。
Overexpression of normal cellular genes may be one mechanism by which malignant cells can acquire a selective growth advantage. The epidermal growth factor receptor and the c-erbB-2 protein are members of the erbB family and are good examples of genes that appear to act through this mechanism. Molecular and biochemical analyses of these two proteins also illustrate how studies of growth factors, growth factor receptors and oncogenic retroviruses may lead to new approaches to diagnosis and treatment. In particular, overexpression of these growth factor receptors has identified clinical subgroups that may respond differently to chemotherapy and provides the opportunity for antibody targeted therapy. Overexpression of these proteins can be identified using immunocytochemistry on both histological sections and fine-needle aspirates, thus enabling these parameters to be assessed preoperatively and to be monitored during therapy.