Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form.
Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form.
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DOI：
10.1002/reg2.54
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Levin M
中科院分区：
文献类型：
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作者：
Durant F;Lobo D;Hammelman J;Levin M
涡虫是复杂的后生动物，当达到正确的解剖结构时，它们会修复身体损伤并停止重塑。该模型系统提供了一个独特的机会来了解大规模解剖稳态如何从单个细胞的活动中产生。涡虫干细胞活性的分子遗传学已取得很大进展。然而，最近的数据还表明，整体模式受到离子和神经递质信号传导组成的生理回路的调节。在这里，我们概述了理解涡虫模式调节的多尺度问题，特别关注通过离子通道和间隙连接（电突触）的生物电信号传导，以及从再生的功能和分子数据中提取解释模型的计算工作。我们提出了一个观点，使用动力系统理论和计算神经科学的概念来解释这个令人着迷的领域的结果。作为模式调节的遗传、生理和计算方法之间的一个易于处理的联系，涡虫模式稳态为再生医学、进化生物学和工程学提供了许多深刻的见解。
Planaria are complex metazoans that repair damage to their bodies and cease remodeling when a correct anatomy has been achieved. This model system offers a unique opportunity to understand how large‐scale anatomical homeostasis emerges from the activities of individual cells. Much progress has been made on the molecular genetics of stem cell activity in planaria. However, recent data also indicate that the global pattern is regulated by physiological circuits composed of ionic and neurotransmitter signaling. Here, we overview the multi‐scale problem of understanding pattern regulation in planaria, with specific focus on bioelectric signaling via ion channels and gap junctions (electrical synapses), and computational efforts to extract explanatory models from functional and molecular data on regeneration. We present a perspective that interprets results in this fascinating field using concepts from dynamical systems theory and computational neuroscience. Serving as a tractable nexus between genetic, physiological, and computational approaches to pattern regulation, planarian pattern homeostasis harbors many deep insights for regenerative medicine, evolutionary biology, and engineering.