Diabesity? No worries, FKBP11 to the rescue.
Diabesity? No worries, FKBP11 to the rescue.
复制标题
糖尿病？
DOI：
10.1016/j.cmet.2022.06.006
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发表时间：
2022
期刊：
影响因子：
29
通讯作者：
Karin,Michael
中科院分区：
文献类型：
--
作者：
Karin,Michael
肥胖引起的 2 型糖尿病或糖尿病与 ER 应激、UPR 激活和胰岛素抵抗有关，其机制尚不清楚。埃雷马等人。 (2022) 报告称，XBP1 靶标 FKBP11 在肥胖小鼠肝脏中受到抑制，其重新表达会激活保护性 UPR 途径，从而恢复胰岛素敏感性。
Obesity-induced type 2 diabetes, or diabesity, is associated with ER stress, UPR activation, and insulin resistance through poorly understood mechanisms. Herrema et al. (2022) report that the XBP1 target FKBP11 is repressed in the obese mouse liver and that its re-expression activates a protective UPR pathway that restores insulin sensitivity.