A retrospective analysis of radiotherapy in the treatment of external auditory canal carcinoma
A retrospective analysis of radiotherapy in the treatment of external auditory canal carcinoma
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DOI：
10.3892/mco.2021.2207
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发表时间：
2021-03-01
影响因子：
1.2
通讯作者：
Nakagawa, Keiichi
中科院分区：
文献类型：
--
作者：
Katano, Atsuto;Takenaka, Ryousuke;Nakagawa, Keiichi
外耳道癌是一种罕见的疾病。本研究旨在评价接受外照射放疗（EBRT）治疗EACC患者的临床结局。本研究回顾性分析了2001年2月至2019年1月期间在东京大学医院接受EBRT治疗的34例EACC连续患者。根据改良匹兹堡分类法进行临床分期。在所有纳入的患者中，7例患者处于EACC的早期阶段（I或II），27例处于晚期阶段（III或IV）。共有16例患者在术前和/或术后接受了EBRT和手术（S+RT），而18例患者接受了确定性放疗（dRT）。S+RT和dRT组的中位处方剂量分别为66和70戈伊。所有患者的中位随访期为22.4个月（范围：2-205个月）。S+RT和dRT组的5年总生存率分别为66.7%和45.1%。整个队列的5年无进展生存率为55.6%（95%置信区间：36.5-71.1%）。共有14例患者在治疗后出现疾病复发，包括11例局部复发和3例远处转移。本研究揭示了EBRT治疗EACC的临床结局。
External auditory canal carcinoma (EACC) is a rare disease. The current study aimed to evaluate the clinical outcomes of patients treated with external beam radiotherapy (EBRT) for EACC. The present study retrospectively reviewed 34 consecutive patients treated for EACC with EBRT between February 2001 and January 2019 at the University of Tokyo Hospital. Clinical staging was performed according to the modified Pittsburgh classification. Of all the included patients, seven patients were in the early stages (I or II) and 27 in the advanced stages (III or IV) of EACC. A total of 16 patients underwent EBRT and surgery (S+RT) pre- and/or postoperatively, while 18 patients underwent definitive radiotherapy (dRT). The median prescribed doses for the S+RT and dRT groups were 66 and 70 Gy, respectively. The median follow-up period for all patients was 22.4 months (range, 2-205 months). The 5-year overall survival rates of the S+RT and dRT groups were 66.7 and 45.1%, respectively. The progression-free survival rate at 5-year was 55.6% (95% confidence interval: 36.5-71.1%) for the entire cohort. A total of 14 patients experienced disease relapse after treatment, consisting of 11 locoregional recurrences and three distant metastases. The current study revealed the clinical outcomes of EBRT for EACC.