Roles of site and timing of the morning insulin injection in type 1 diabetes.
Roles of site and timing of the morning insulin injection in type 1 diabetes.
复制标题
早晨胰岛素注射部位和时间在 1 型糖尿病中的作用。
DOI：
10.1016/s0022-3476(83)80577-0
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Santiago,JV
中科院分区：
文献类型：
--
作者：
Witt,MF;White,NH;Santiago,JV
为了研究注射胰岛素的部位和时间对早餐后血糖浓度的影响，23 名 1 型糖尿病儿童在一天早餐前 5 分钟注射常用的短效和中效胰岛素混合物，并在第二天早餐前 15 至 60 分钟注射胰岛素，具体取决于他们早上 7:00 的空腹血糖浓度。 13 名儿童在四肢接受了胰岛素治疗，10 名儿童在腹壁接受了胰岛素治疗。两个注射部位的血浆胰岛素和葡萄糖模式相似。当早餐前 30 至 60 分钟注射胰岛素时，早餐后的平均峰值葡萄糖增量显着较低，早餐后第一小时内游离胰岛素值的平均增量较高。因此，通过按空腹毛细血管葡萄糖浓度的比例增加注射和早餐之间的间隔，可以显着降低早餐后高血糖。早上注射胰岛素的时间可能比注射部位更重要。
To investigate the effect of site and timing of insulin injection on post-brekfast plasma glucoseconcentration, 23 children with type 1 diabetes were given their usual mixture of short- and intermediate-acting insulin five minutes prior to breakfast on one day and between 15 and 60 minutes before breakfast on the alternate day, depending on their 7:00amfasting blood glucose concentration. Thirteen children received insulin in an extremity, and 10 in the abdominal wall. Plasma insulin and glucose patterns were similar for the two injection sites. The mean post-breakfast peak glucose increment was significantly lower and the mean increment in free insulin values during the first hour after breakfast was higher on the day when insulin preceded breakfast by 30 to 60 minutes. Thus, significant reductions in post-breakfast hyperglycemia can be achieved by increasing the interval between the injection and breakfast in proportion to the fasting capillary glucose concentration. The timing of the morning insulin injection may be more important than the injection site.