Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging.
Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging.
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DOI：
10.3389/fphys.2021.733696
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发表时间：
2021
影响因子：
4
通讯作者：
Camici GG
中科院分区：
文献类型：
--
作者：
Ministrini S;Puspitasari YM;Beer G;Liberale L;Montecucco F;Camici GG
Sirtuin 1 （SIRT1）是一种组蛋白去乙酰化酶，属于Sirtuins家族，是一类具有多种代谢功能的烟酰胺腺嘌呤二核苷酸（NAD+）依赖性酶。SIRT1定位于细胞核和细胞质中，参与对多种刺激（包括代谢刺激）的细胞存活调节。SIRT1的表达与寿命有关，在动物模型和人类中，SIRT1的表达随着年龄的增长而降低，SIRT1的缺乏被认为是年龄相关心血管疾病的潜在中介。在这篇综述中，我们将总结SIRT1功能和数量缺陷与细胞衰老和衰老的广泛证据，特别是它们在决定内皮功能障碍和随之而来的心血管疾病中的作用。最后，我们概述了该主题的翻译观点，以突出缺失的证据和未来的研究步骤。
Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions. SIRT1 localizes in the nucleus and cytoplasm, and is implicated in the regulation of cell survival in response to several stimuli, including metabolic ones. The expression of SIRT1 is associated with lifespan and is reduced with aging both in animal models and in humans, where the lack of SIRT1 is regarded as a potential mediator of age-related cardiovascular diseases. In this review, we will summarize the extensive evidence linking SIRT1 functional and quantitative defects to cellular senescence and aging, with particular regard to their role in determining endothelial dysfunction and consequent cardiovascular diseases. Ultimately, we outline the translational perspectives for this topic, in order to highlight the missing evidence and the future research steps.
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