Maturational changes related to dopamine in the effects of d-amphetamine, cocaine, nicotine, and strychnine on seizure susceptibility
Maturational changes related to dopamine in the effects of d-amphetamine, cocaine, nicotine, and strychnine on seizure susceptibility
复制标题
d-苯丙胺、可卡因、尼古丁和士的宁对癫痫易感性影响中与多巴胺相关的成熟变化
作者：
C. Greer;H. Alpern
在两个年龄组（30 天和 120 天）的短睡眠小鼠中研究了四种神经兴奋剂（d-苯丙胺、可卡因、尼古丁和士的宁）对肌阵挛和阵挛性癫痫易感性的影响。安非他明和可卡因降低了年轻小鼠对肌阵挛的敏感性，并增加了成熟小鼠对肌阵挛的敏感性。这些作用通过氟哌啶醇预处理减弱，表明多巴胺能系统的介导。安非他明不会改变任一年龄组小鼠的阵挛易感性，而可卡因会影响阵挛易感性和肌阵挛。这些作用并没有被氟哌啶醇减弱，表明除了多巴胺之外的系统也有调节作用。尼古丁降低了肌阵挛的易感性并增加了阵挛的易感性，而士的宁则增加了这两种类型癫痫发作的易感性。然而，氟哌啶醇未能改变任何这些作用。这些结果与我们之前的工作一致，该工作表明这些小鼠的多巴胺能机制在 30 至 120 天龄之间经历了显着的发育变化。
The effects of four neural excitants (d-amphetamine, cocaine, nicotine, and strychnine) on myoclonic and clonic seizure susceptibility were investigated in two age groups (30 and 120 days) of short-sleep mice. Amphetamine and cocaine decreased susceptibility to myoclonus in young mice and increased susceptibility in mature mice. These effects were attenuated by pretreatment with haloperidol, indicating mediation by a dopaminergic system. Amphetamine did not alter clonic susceptibility in either age group of mice, whereas cocaine affected clonic susceptibility and myoclonus. These effects were not attenuated by haloperidol, indicating mediation by systems other than dopamine. Nicotine decreased susceptibility to myoclonus and increased susceptibility to clonus, whereas strychnine increased susceptibility to both types of seizure. Haloperidol, however, failed to alter any of these effects. These results are consistent with our previous work which suggests that a dopaminergic mechanism in these mice undergoes marked developmental changes between 30 and 120 days of age.