IMMUNOHISTOCHEMICAL LOCALIZATION OF ANDROGEN RECEPTOR IN THE HUMAN ENDOMETRIUM, DECIDUA, PLACENTA AND PATHOLOGICAL CONDITIONS OF THE ENDOMETRIUM
IMMUNOHISTOCHEMICAL LOCALIZATION OF ANDROGEN RECEPTOR IN THE HUMAN ENDOMETRIUM, DECIDUA, PLACENTA AND PATHOLOGICAL CONDITIONS OF THE ENDOMETRIUM
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DOI：
10.1093/oxfordjournals.humrep.a137595
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发表时间：
1992-11-01
影响因子：
6.1
通讯作者：
MORI, T
中科院分区：
文献类型：
--
作者：
HORIE, K;TAKAKURA, K;MORI, T
雄激素受体的免疫组织化学定位在人类子宫内膜在不同阶段的月经周期和绝经后时期，在蜕膜和胎盘的早孕，并在子宫内膜的几种病理条件进行了研究。在月经周期的任何时期，子宫内膜腺细胞和子宫内膜间质细胞均呈阳性核染色。功能层子宫内膜间质细胞的染色强度高于基底层，而两层子宫内膜腺细胞的染色强度相同。子宫肌层几乎没有染色。即使在绝经后，子宫内膜腺体和间质细胞也显示与绝经前子宫内膜基底层相同的染色模式，子宫内膜间质细胞的染色强度较弱。早孕蜕膜和胎盘中，蜕膜细胞和滋养层细胞呈阳性染色，胎盘基质细胞无阳性染色。雄激素受体在子宫腺肌病、子宫内膜异位症和子宫内膜癌中也有表达。虽然子宫内膜的增殖和分化主要由雌激素和孕激素受体介导，但雄激素受体可能在调节这些变化中起一定作用。提示其可能参与子宫内膜的生理和病理变化。
The immunohistochemical localization of the androgen receptor in the human endometrium at various stages of the menstrual cycle and post-menopausal period, in decidua and placenta of early pregnancy, and in several pathological conditions of the endometrium has been investigated. At any phase of the menstrual cycle, both endometrial glandular cells and endometrial stromal cells showed positive nuclear staining. Endometrial stromal cells of the functional layer showed stronger staining than those of the basal layer, but endometrial glandular cells of both layers showed the same staining intensity. There was little staining in myometrium. Even after menopause, endometrial glandular and stromal cells showed the same staining pattern as the basal layer of pre-menopausal endometrium and the staining intensity of endometrial stromal cells was weak. In decidua and placenta of early pregnancy, decidual and trophoblastic cells showed positive staining and there was no staining in the stromal cells of placenta. The expression of the androgen receptor was also detected in adenomyosis, endometriosis and endometrial carcinoma. Although the proliferation and differentiation of endometrium are mediated mainly by oestrogen and progesterone receptors, the androgen receptor may play some role in modulating these changes. These results suggest that it may be involved in both physiological and pathological changes of the endometrium.