Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental implants: a case report
Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental implants: a case report
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DOI：
10.1186/s40729-017-0074-6
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发表时间：
2017-03-30
影响因子：
2.7
通讯作者：
Kishimoto, Hiromitsu
中科院分区：
文献类型：
--
作者：
Zushi, Yusuke;Takaoka, Kazuki;Kishimoto, Hiromitsu
我们报告了一例66岁的严重骨质疏松症女性患者，她的牙种植体周围发生了双膦酸盐相关的颌骨骨坏死（BRONJ），她成功地接受了下颌骨的teriparbital和死骨切除术治疗。经过5个月的三联疗法，死骨分离进展，并在全身麻醉下进行了死骨切除术。术后5个月，在死骨切除术区域的骨缺损周围观察到新骨形成。重复计算机断层扫描图像显示下颌骨骨缺损改善。这些结果表明，特立帕肽在治疗牙种植体周围晚期BRONJ方面具有有益作用。
We report a case of a 66-year-old severely osteoporotic woman with bisphosphonate-related osteonecrosis of the jaw (BRONJ) around her dental implants, who was treated successfully with teriparatide and sequestrectomy of the mandible. After 5 months of teriparatide therapy, the sequestrum separation had progressed and a sequestrectomy was performed under general anesthesia. Five months after the operation, new bone formation was observed around the bone defect in the region of the sequestrectomy. A repeat computed tomographic image revealed improvement in the bone defect in the mandible. These results suggest that teriparatide provides beneficial effects in the treatment of advanced BRONJ around dental implants.