Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.
Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.
复制标题
边缘异常红细胞在血液疾病的计算模型中诱导病理性血管应力波动。
DOI：
10.1101/2023.05.16.541016
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Graham,MichaelD
中科院分区：
文献类型：
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作者：
Cheng,Xiaopo;Caruso,Christina;Lam,WilburA;Graham,MichaelD
镰状细胞病等红细胞疾病影响着全球数十亿人。虽然很多人关注的是异常红细胞的特性改变和相应的血流动力学改变，但红细胞紊乱也与血管功能障碍有关，其起源尚不清楚，可引起包括中风在内的严重后果。很少有研究探讨红细胞的生物物理改变是否影响血管功能。我们使用详细的血液计算模型，可以表征血液疾病中的细胞分布和血管压力，并将模拟结果与实验观察结果进行比较。异常红细胞体积更小，硬度更高，集中在血管壁附近（边缘），因为与正常细胞相比，其物理性质存在差异。在弯曲的通道中，这些细胞分布不均，表明几何形状的重要性，体现了微循环的几何复杂性。边缘细胞在血管壁上产生大的瞬时应力波动，表明了观察到的血管炎症的机制。
Red blood cell (RBC) disorders such as sickle cell disease affect billions worldwide. While much attention focuses on altered properties of aberrant RBCs and corresponding hemodynamic changes, RBC disorders are also associated with vascular dysfunction, whose origin remains unclear and which provoke severe consequences including stroke. Little research has explored whether biophysical alterations of RBCs affect vascular function. We use a detailed computational model of blood that enables characterization of cell distributions and vascular stresses in blood disorders and compare simulation results with experimental observations. Aberrant RBCs, with their smaller size and higher stiffness, concentrate near vessel walls (marginate) because of contrasts in physical properties relative to normal cells. In a curved channel exemplifying the geometric complexity of the microcirculation, these cells distribute heterogeneously, indicating the importance of geometry. Marginated cells generate large transient stress fluctuations on vessel walls, indicating a mechanism for the observed vascular inflammation.