The sudden infant death syndrome.
The sudden infant death syndrome.
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DOI：
10.1056/nejmra0803836
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发表时间：
2009-08-20
期刊：
影响因子：
--
通讯作者：
Thach BT
中科院分区：
文献类型：
--
作者：
Kinney HC;Thach BT
本章总结了婴儿猝死综合征（SIDS）的神经病理学的最新进展。2015年，SIDS婴儿的海马异常被描述，包括颗粒细胞分散及其变体，齿状双胺化。已经报道了SIDS中的各种下丘脑异常，其相关性在于下丘脑是中枢稳态网络的关键节点，并且关键地参与整个动物的稳态。在至少一些SIDS脑中发现的与缺氧缺血性损伤一致的病变可能继发于中枢心肺功能损害，并反映了致死性事件前的亚临床远程和/或慢性脑干功能障碍。然而，小岛屿发展中国家越来越被概念化，认为婴儿同时具有潜在的脆弱性、外部压力和关键的发育期。在中枢稳态网络的不同皮质和皮质下部位观察到的异常提示了分布式脑网络的功能障碍。
This chapter summarizes the recent advances in the neuropathology of sudden infant death syndrome (SIDS). In 2015, hippocampal abnormalities were described in SIDS infants, including granule cell dispersion and its variant, dentate bilamination. A variety of hypothalamic abnormalities in SIDS have been reported, of relevance as the hypothalamus is the key node of the central homeostatic network, and is involved critically in the homeostasis of the whole animal. The lesions consistent with hypoxic‐ischemic insult that are found in at least some SIDS brains may be secondary to central cardiorespiratory compromise and reflect subclinical remote and/or chronic brainstem dysfunction prior to the lethal event. SIDS is increasingly conceptualized, however, as the simultaneous convergence upon the infant of an underlying vulnerability, an exogenous stressor, and a critical developmental period. The observations of abnormalities in different cortical and subcortical sites of the central homeostatic network suggest dysfunction within a distributed brain network.