mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK.
mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK.
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mir-101-3p 是三阴性乳腺癌肿瘤代谢的关键调节因子，靶向 AMPK
DOI：
10.18632/oncotarget.9072
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Liu P;Ye F;Xie X;Li X;Tang H;Li S;Huang X;Song C;Wei W;Xie X
mir-101-3p has been reported to be a tumor suppressor and a promising therapeutic target in cancer. Recently, AMPK dysfunction has been highlighted in cancers, including breast cancer. The aim of this study is to investigate the biological roles of mir-101-3p and AMPK in breast cancer. Our research demonstrated that AMPK was up-regulated in breast cancer tissues and cell lines, especially in triple negative breast cancer (TNBC). High-expression of AMPK correlated with poor outcome in both total breast cancer and TNBC patients. Ectopic expression of AMPK improved glucose uptake, glycolysis, proliferation of TNBC cells in vitro and its tumorigenicity in vivo. AMPK was predicted to be a direct target of mir-101-3p. The luciferase reporter assay was performed to certificate this prediction. The expression of AMPK was suppressed by transfection of mir-101-3p in TNBC cells. Over-expression of mir-101-3p or knock-down of AMPK inhibited glucose metabolism and proliferation of TNBC cells in vitro. Our study provides evidence that mir-101-3p- AMPK axis could be a promising therapeutic target in TNBC targeting tumor metabolism.
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影响因子：
6.7
作者：
Jeon SM;Hay N
通讯作者：
Hay N
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影响因子：
--
作者：
Liu X;Tang H;Chen J;Song C;Yang L;Liu P;Wang N;Xie X;Lin X;Xie X
通讯作者：
Xie X
影响因子：
2.8
作者：
Courtnay, Rupert;Ngo, Darleen C.;Karagiannis, Tom C.
通讯作者：
Karagiannis, Tom C.
DOI：
10.1158/1940-6207.capr-10-0333
发表时间：
2011-07
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Hao Y;Gu X;Zhao Y;Greene S;Sha W;Smoot DT;Califano J;Wu TC;Pang X
通讯作者：
Pang X
DOI：
10.1158/1078-0432.ccr-14-3300
发表时间：
2015-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Hardie DG
通讯作者：
Hardie DG