Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys
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DOI：
10.1126/science.1124226
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发表时间：
2006-06-09
期刊：
影响因子：
56.9
通讯作者：
Nabel, GJ
中科院分区：
文献类型：
--
作者：
Letvin, NL;Mascola, JR;Nabel, GJ
疫苗诱导的细胞免疫只能短暂地控制感染猿猴免疫缺陷病毒（SIV）的猴子中的病毒复制，从而引发了这样的问题：这种艾滋病疫苗是否有效。我们用质粒 DNA 和编码 SIV 蛋白的复制缺陷型腺病毒载体对猴子进行免疫接种，然后用致病性 SIV 攻击它们。尽管这些猴子表现出病毒血症的减少仅限于 SIV 感染的早期阶段，但它们的生存期却延长了。这种存活与保留的中央记忆CD4(+) T淋巴细胞有关，并且可以通过疫苗诱导的细胞免疫反应的强度来预测。这些疫苗功效的免疫相关性应指导人类艾滋病疫苗的评估。
Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV) - infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4(+) T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.