B Cell-Activating Factor as a New Potential Marker in Inflammatory Bowel Disease
B Cell-Activating Factor as a New Potential Marker in Inflammatory Bowel Disease
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B 细胞激活因子作为炎症性肠病的新潜在标志物
DOI：
10.1007/s10620-016-4136-z
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发表时间：
2016-09-01
影响因子：
3.1
通讯作者：
Zou, Kaifang
中科院分区：
文献类型：
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作者：
Zhang, Peipei;Liu, Xiaojing;Zou, Kaifang
B细胞激活因子(BAFF)被认为是B细胞和T细胞免疫反应的调节因子，并与自身免疫和B细胞恶性肿瘤的炎症过程有关。本研究旨在探讨BAFF在炎症性肠病(IBD)中的表达和浓度及其与IBD的鉴别诊断价值。采用酶联免疫吸附试验检测血清和粪便中BAFF水平。分析IBD患者活检组织中BAFF的表达。血清BAFF浓度中位数(第25~75百分位数)CD组为1430(1105~1624)，UC组为1472(1018~1772)，健康对照组为977(482~1345)。血清BAFF对诊断活动期IBD的敏感性为%，特异性为93%。IBD患者活检组织中BAFF的表达显著增加。粪便BAFF浓度CD组为369(326-493)pg/ml，UC组为542(358-1758)pg/ml，IBS组为294(287-299)pg/ml，健康对照组为295(284-309)pg/ml。粪便BAFF对诊断活动期IBD的敏感性为90%，特异性为96%。BAFF与IBD之间的新关联似乎证实了BAFF可能调节这些疾病的炎症过程，它似乎是IBD的一个潜在标记物。
B cell-activating factor (BAFF) has been proposed to be a regulator of B cell and T cell immune responses and be associated with inflammatory processes in autoimmunity and B cell malignancies. No study has reported the role of BAFF in inflammatory bowel disease (IBD).The purpose of this study was to investigate expression and concentrations of BAFF in IBD and determine its value to discriminate patients with IBD.Seventy-eight ulcerative colitis (UC) patients, 37 Crohn's disease (CD) patients, 12 irritable bowel syndrome (IBS) patients and 44 healthy controls were recruited. We examined serum and faecal BAFF levels using enzyme-linked immunosorbent assay. Intestinal BAFF expression was analysed in biopsies obtained from IBD patients. Intestinal mucosa localization of BAFF was conducted by immunofluorescence.The median (25th-75th percentile) serum BAFF concentration (pg/ml) was 1430 (1105-1624) in CD patients, 1472 (1018-1772) in UC patients and 977 (482-1345) in healthy controls. Serum BAFF was 64 % sensitive and 93 % specific for identifying active IBD from healthy controls. The BAFF expression was significantly increased in biopsy specimens from IBD patients. Fecal BAFF concentration was 369 (326-493) pg/ml in CD patients, 542 (358-1758) pg/ml in UC patients, 294 (287-299) pg/ml in IBS patients and 295 (284-309) pg/ml in healthy controls. Fecal BAFF was 90 % sensitive and 96 % specific for identifying active IBD from healthy controls and IBS patients.The novel association between BAFF and IBD seems to identify that BAFF might regulate the inflammatory process in these diseases and it appears to be a potential marker of IBD.