Interference Localized Surface Plasmon Resonance Nanosensor Tailored for the Detection of Specific Biomolecular Interactions
Interference Localized Surface Plasmon Resonance Nanosensor Tailored for the Detection of Specific Biomolecular Interactions
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DOI：
10.1021/ac902008x
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发表时间：
2010-02-15
影响因子：
7.4
通讯作者：
Tamiya, Eiichi
中科院分区：
文献类型：
--
作者：
Hiep, Ha Minh;Yoshikawa, Hiroyuki;Tamiya, Eiichi
本文提出了一种用于干涉局域表面等离子体共振(ILSPR)传感器的新型传感纳米材料。ILSPR是基于等离子体金纳米颗粒，在衬底上有多层多孔氧化铝(Al)和铝(Al)的光子薄膜。通过可控的透明Al_2O_3层和高反射的M层，我们的新纳米材料能够检测到周围环境的折射率(RI)变化，以及当iLSPR表面被生物功能化时，包括生物素和亲和素、5-氟尿嘧啶(5-FU)及其抗体(抗5-FU)在内的生物分子之间的特异性相互作用。我们的模型纳米结构将为展示其他贵金属纳米颗粒的等离子体性质和开发其他功能相似的纳米传感器开辟道路，然后可以扩展到多阵列。
In this paper, we present an innovative sensing nanomaterial for an interference localized surface plasmon resonance (iLSPR) sensor. The iLSPR is based on plasmonic gold nanoparticles with photonic thin-film multilayers of porous aluminum oxide (Al2O3) and aluminum (Al) on a substrate. With a controllable transparent Al2O3 layer and a highly reflective M layer, our new nanomaterial was able to detect refractive index (RI) changes of the surrounding environment and the specific interaction of biomolecules including biotin and avidin, 5-fluorouracil (5-FU) and its antibody, anti-5-fluorouracil (anti 5-FU), when the iLSPR surfaces were biologically functionalized. Our model nanostructure will open the way to display the plasmonic properties of other noble metal nanoparticles and to develop other functionally similar nanosensors, which could then be expanded into multiarrays.