IS THERE A BALANCE BETWEEN OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE SYSTEM DURING DEVELOPMENT
IS THERE A BALANCE BETWEEN OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE SYSTEM DURING DEVELOPMENT
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发表时间：
2005
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通讯作者：
R. Ahmed
中科院分区：
文献类型：
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作者：
R. Ahmed
摘要：鉴于抗氧化酶和活性氧在生物学上的重要性，有必要对它们之间的关系进行文献综述。本综述的主要目的不仅揭示了不同物种的促氧化和抗氧化过程的基线工作，而且阐明了自由基衰老理论的机制。综上所述，这一综述表明，自由基水平的下降与抗氧化酶活性的增加是相辅相成的，但在发育过程中，氧自由基的产生与抗氧化防御酶之间也存在临界平衡。然而，由于生物系统中活性氧的寿命较短，直接观察存在困难，因此这些结果仍未被完全接受。
SUMMARY : For the reason of the biological importance of antioxidant enzymes and reactive oxygen species, it was deemed important to survey the literature for reports on the relation between them. The main aim of this overview not only uncovered the baseline works on aspects of prooxidant and antioxidant processes in different species, but also illuminated the mechanism of the free radical theory of aging. Taken together, this review suggest that the decline in levels of free radicals revealed a coupled with increased antioxidant enzyme activities and the reverse is true, but also critical balance between the generation of oxygen free radicals and antioxidant defense enzymes during development. However, these results are not still entirely accepted because of the difficulties of the direct observation of the active oxygen species in biological systems due to their short lifetime.