Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling.
Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling.
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DOI：
10.1042/bst20220616
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发表时间：
2023-04-26
影响因子：
3.9
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中科院分区：
文献类型：
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蛋白质稳态（proteostasis）对于细胞功能和有机体健康是必不可少的，并且需要蛋白质合成、折叠、运输和周转的协同作用。在有性繁殖的生物体中，永生的生殖细胞系将遗传信息传递给几代人。越来越多的证据表明，蛋白质组的完整性对生殖细胞基因组稳定性的重要性。由于配子发生涉及非常活跃的蛋白质合成，并且需要高度的能量，因此它对蛋白质稳态调节具有独特的要求，并且对压力和营养供应敏感。热休克因子1（HSF 1）是细胞对胞质和核蛋白错误折叠反应的关键转录调节因子，在种系发育中具有进化保守的作用。类似地，胰岛素/胰岛素样生长因子-1（IGF-1）信号传导，一种主要的营养感应途径，影响配子发生的许多方面。在这里，我们专注于HSF 1和IIS审查其在生殖细胞蛋白质稳态中的作用，并讨论在压力和衰老过程中配子质量控制的影响。
Protein homeostasis (proteostasis) is essential for cellular function and organismal health and requires the concerted actions of protein synthesis, folding, transport, and turnover. In sexually reproducing organisms, the immortal germline lineage passes genetic information across generations. Accumulating evidence indicates the importance of proteome integrity for germ cells as genome stability. As gametogenesis involves very active protein synthesis and is highly energy-demanding, it has unique requirements for proteostasis regulation and is sensitive to stress and nutrient availability. The heat shock factor 1 (HSF1), a key transcriptional regulator of cellular response to cytosolic and nuclear protein misfolding has evolutionarily conserved roles in germline development. Similarly, insulin/insulin-like growth factor-1 (IGF-1) signaling, a major nutrient-sensing pathway, impacts many aspects of gametogenesis. Here, we focus on HSF1 and IIS to review insights into their roles in germline proteostasis and discuss the implications on gamete quality control during stress and aging.