Damped Oscillation in the Cyanobacterial Clock System
Damped Oscillation in the Cyanobacterial Clock System
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蓝藻时钟系统中的阻尼振荡
DOI：
10.1007/978-3-030-72158-9_12
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Iwasaki Hideo
中科院分区：
文献类型：
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作者：
Ito Hiroshi;Murayama Yoriko;Kawamoto Naohiro;Seki Motohide;Iwasaki Hideo
虽然时间生物学家已经假设昼夜节律是自我维持的，但我们在这里报告了蓝藻昼夜节律系统中抑制振荡的两个例子。首先，低温将自我维持的KaiC磷酸化节律转变为阻尼性振荡。第二，KaiA基因的缺失在生物发光节律中表现出抑制的振荡。这些被抑制的节律与周期性的环境变化共振，然后恢复其振荡幅度。数值实验证实，具有自持续振荡特性的生化网络是罕见的。进化搜索显示，光周期可能有助于进化昼夜节律的自我可持续性。虽然阻尼式振荡器还没有得到实质性的时间生物学分析，但我们的发现表明，生物钟可以很容易地因环境或遗传扰动而转变为阻尼式振荡器，并可能起到半时钟系统的作用。
Although chronobiologists have postulated self-sustainability in circadian clocks, we report here two examples of damped oscillation in the cyanobacterial circadian system. First, low temperature transformed the self-sustained KaiC phosphorylation rhythm into damped oscillations. Second, deletion of thekaiAgene showed damped oscillation in the bioluminescent rhythm. These damped rhythms resonated with periodical environmental changes and then recovered their oscillation amplitudes. Numerical experiments confirmed that biochemical networks with the characteristic of self-sustained oscillation are rare. Evolutionary searches revealed that photoperiodism might contribute to evolving the self-sustainability of circadian rhythms. Although damped oscillators have not received substantial chronobiological analyses, our findings suggest that the circadian clock can easily transform into a damped oscillator by environmental or genetic perturbation and might function as a semi-clock system.