Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with be nign breast disease
Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with be nign breast disease
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DOI：
10.1016/j.cdp.2007.02.004
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Helzlsouer, Kathy J.
中科院分区：
文献类型：
--
作者：
Gallicchio, Lisa;McSorley, Meghan A.;Helzlsouer, Kathy J.
背景资料：在绝经后妇女中进行了一项队列研究，以确定选定的肥胖相关基因（PPARG、LPL、LEPR、PON 1、PON 2、TNF-α）中的遗传多态性是否与良性乳腺疾病（BBD）进展为乳腺癌相关，以及选定的多态性是否改变了BBD妇女体重与乳腺癌之间的关联。方法：在一项正在进行的队列研究的参与者中，994名白人绝经后妇女因BBD接受了乳腺活检。在这些妇女中，有61人后来患上了乳腺癌。在1989年的基线时进行了简短的问卷调查。使用从1989年收集的血液中提取的DNA确定基因型。结果：在该队列中，体重指数（BMI）与患乳腺癌的风险呈正相关。相反，PON 1（Gln 192 Arg）和LEPR（IVS 2 + 6920）的多态性与浸润性乳腺癌发生风险降低相关。PPARG、PON 2、LPL或TNF的多态性与乳腺癌风险或多态性与BMI和乳腺癌风险之间的相互作用没有统计学显著相关性。结论：研究结果表明，具体。PON]和LEPR基因的多态性可能在绝经后白人妇女中BBD向乳腺癌的进展中起作用。(C)2007年国际预防肿瘤学会。由爱思唯尔有限公司出版。保留所有权利。
Background: A cohort study was conducted among post- menopausal women to determine whether genetic polymorphisms in selected obesity-related genes (PPARG, LPL, LEPR, PON1, PON2, TNF-alpha) were associated with the progression of benign breast disease (BBD) to breast cancer and whether the selected polymorphisms modified the association between body mass and breast cancer among women with BBD. Methods: Among participants in an ongoing cohort study, 994 Caucasian post-menopausal women had a breast biopsy for BBD. Of these women, 61 subsequently developed breast cancer. A short questionnaire was administered at baseline in 1989. Genotypes were determined using DNA extracted from blood collected in 1989. Results: In this cohort, body mass index (BMI) was positively associated with the risk of developing breast cancer. In contrast, polymorphisms in PON1 (Gln192Arg) and LEPR (IVS2 + 6920) were associated with a decreased risk of developing invasive breast cancer. No statistically significant associations were observed for polymorphisms in PPARG, PON2, LPL, or TNF and breast cancer risk or for interactions between the polymorphisms and BMI and breast cancer risk. Conclusions: The findings suggest that specific. polymorphisms in the PON] and LEPR genes may play a role in progression of BBD to breast cancer among post-menopausal Caucasian women. (C) 2007 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.